White Papers, Technical Notes, and Case Studies: What’s the Difference?

Learn the key differences between white papers, technical notes, and case studies to choose the best format and message for your marketing goals.

Here’s a question for science content marketers: how would you define the difference between a white paper, a technical note, and a case study? 

Meme of Jim Halpert from the TV show The Office asking what a rundown is.

In S5E23 of The Office, new branch manager Charles asks an overly confident Jim Halpert to get him a “rundown” of his clients. Jim enthusiastically agrees — but then turns to the camera and asks: What the hell is a rundown?

I felt the same confusion when I was tasked with writing my first white paper. I’d written research articles, blogs, news stories, but never a white paper. What information did it need to include? How technical or formal would it be? Would it have a specific structure? 

Unlike Jim, I did ask my editor for more details. But with so many different types of technical content formats available to content marketers, it’s easy to lose sight of what you’re writing about and why. For example, you may encounter a so-called technical note that reads more like a case study but without a specific case that is being studied. 

So, to riff on the words of everyman Jim Halpert:

What the hell is the difference between a white paper, technical note, and case study?

All three formats follow a problem-challenge-solution arc. However, they all serve a distinct marketing purpose. Understanding those differences will help you choose the right format, message, and level of detail for your goals.

What is a White Paper?

A white paper examines a broader problem or trend within a given field and proposes a potential solution, often one provided by whoever is writing, publishing, or sponsoring the white paper. The first white papers were government documents meant to explain policy decisions. Now, they’re frequently used in B2B contexts as a tool of education and persuasion.

While white papers can include technical information, this is not the focus. The audience isn’t meant to be able to reproduce the experiments or designs they describe. Instead, white papers are targeted at decision-makers who need a comprehensive understanding of an issue.

White papers can be a powerful tool for establishing thought leadership within an industry. They often address emerging trends, regulatory shifts, or technological advances, and include data, expert insights, and references to support their claims.

When Should You Use a White Paper?

  • Audience: Decision-Makers, Decision-Influencers
  • Purpose: Introduce a broader problem and propose a solution
  • Content: Expert perspectives, data, and context (not step-by-step methods)
  • Ask Yourself: Does my solution fit into a broader industry trend or challenge?

What is a Technical or Application Note? 

examples of C&EN App Notes

A technical note—which is often synonymous with an application note—presents a specific problem and offers a detailed, reproducible solution. Unlike white papers, technical notes are highly experimental and method-driven. They describe conditions, procedures, and outcomes in depth, making them ideal for researchers or engineers solving specific technical issues.

These documents often include step-by-step protocols, data analysis, and diagrams. A reader could feasibly evaluate the quality of the protocol, assess if the information is applicable to their own work, and, eventually, replicate the protocol.

When Should You Use a Technical Note?

  • Audience: Scientists, engineers, and technical professionals
  • Purpose: Share reproducible methods and results for your audience to assess
  • Content: Experimental details, data, and outcomes
  • Ask Yourself: Do I have a specific method or result using my product that others could apply or replicate?

What is a Case Study?

A Case Study by BrandLab on a Cresset White Paper
View examples in our Case Study Library.

A case study tells the story of a real-world problem and how your product or service solved it. It often includes customer testimonials, metrics, and before-and-after comparisons.

Case studies are powerful tools for building credibility and trust, especially when a product or solution is complex and multifaceted—like consulting services or enterprise software. Case studies show—not just tell—how your solution works in practice. 

When Should You Use a Case Study?

  • Audience: Bottom-of-funnel content for decision-makers and technical experts 
  • Purpose: Demonstrate real-world application and results of your product
  • Content: Customer stories, outcomes, and testimonials
  • Ask Yourself: Do I have a real-world success story that highlights my product’s impact?

Why Does it Matter?

Understanding the differences between white papers, technical notes, and case studies isn’t necessarily about understanding the terminology. In fact, it would be a stretch to say there is one accepted definition for these content formats.  

What is important is your clarity in purpose when creating that content and the resulting ability of the content to support your content strategy. So, before tasking yourself, your team, or your marketing partners with creating a white paper, technical note, or case study, first align your goals and ask questions like:

  • Who is this content for?
  • What is the message I need them to understand?
  • How do I want them to use this information? 

With deeper understanding of who the proposed content is for and what your is, then you can decide on what format the content will take. Ideally, the result will be content with a clear purpose that will meet your audience’s expectations and needs.

So, before you embark upon creating a new piece of content, make sure you’ve first clearly defined your goal, your audience, and your message. Then, go forth and create a white paper, technical note, case study, or whatever other type of content that best fits your criteria.

Start generating more leads today!

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Sammi Wang

Account Manager
sammi@echinachem.com

Sammi is the General Manager China of eChinaChem, where she has worked since 2005 and previously served as Vice President and Sales Manager. eChinaChem offers news media, conferences and events, as well as education and training services in the chemical, pharmaceutical, and healthcare sectors in China. Before eChinaChem, she worked at GlobalSources as an Account Executive. Sammi received her MBA from the University of International Business and Economics and her undergraduate degree from Yantai University.

Sales Territory: China 

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Kyra Luttermann

Account Manager
kl@intermediapartners.de

Kyra Luttermann is an IT & AI Specialist with a strong academic background, complemented by deep knowledge in Philosophy. She holds advanced training from the University of Oxford in Artificial Intelligence. Kyra excels in AI prompting, consulting, and sales, effectively helping customers reach their target audiences. Since joining IMP and ACS in 2023, she has been instrumental in advancing ACS’s mission, representing the next generation of innovative leaders in the field.

Sales Territories: Germany, Austria, Switzerland, The Netherlands, Ireland, Scandinavia, Belgium, France, Italy, Spain, Portugal, East Central Europe and The Middle East

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Uwe Riemeyer

Uwe Riemeyer is a seasoned Global Media Specialist with over 25 years of experience in media sales, consulting, and planning, primarily for the global chemical industry. Since 1997, he has been affiliated with ACS and operates his own successful media business in Germany. Uwe’s expertise spans all B2B industry segments and related media outlets, supported by a solid foundation in economics and an initial career in the automotive industry. His comprehensive knowledge and strategic insights make him a key player in media planning and consulting.

Sales Territories: Germany, Austria, Switzerland, The Netherlands, Ireland, Scandinavia, Belgium, France, Italy, Spain, Portugal, East Central Europe and The Middle East

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Jim Beckwith

Account Manager
j.beckwith@jgeco.com

Jim Beckwith brings his skills to ACS after a lengthy media consulting career in both for-profit and non-profit media. He specializes in helping advertising partners “connect the dots” between their marketing/lead generation objectives and the wide range of opportunities in the ACS Media portfolio. Jim works with advertisers based in the Southeast and Eastern U.S.

Sales Territories: US East Coast and Southeast 

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Beth Kurup

Beth Kurup is an Account Manager based in Los Angeles, California. She handles marketing programs for clients in the Western United States. Beth’s media and marketing background aid her in creating strategic plans for clients with a focus on details and meeting objectives.  

Sales Territory: US West Coast Sales

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Pete Manfre

Account Manager
p_manfre@acs.org

Except for a brief hiatus in 2022, Pete Manfre has been a fixture at ACS since 2015, helping clients navigate the complex B2B digital landscape. Over the years, Pete has gained the trust of many science marketing leaders with his honest and straightforward approach. His unique insights and expertise have benefitted the small companies looking to gain traction with new potential customers and the well-known industry brands looking to elevate their thought leadership and capture bigger market-share.

Sales Territories: ACS Meetings Exhibition and Sponsorships (ACS Spring, ACS Fall and Pacifichem) 

Chris Nolan

Chris Nolan

Chris Nolan has been creating solutions for C&EN and ACS advertisers since 2017. After growing the western US territory to $1.6M from $800k, he was promoted to national sales manager in 2021. He is based in Chicago and covers the central US and Canada. His background in media solutions includes successful production for such well known global media brands as Fortune, INC, Fast Company, The Nikkei, the FT, and The Globe & Mail.

Sales Territories: US Midwest and Northeast East Coast; Canada; Australia; New Zealand and South America

Mariam Agha 

Account & Marketing Manager
CENBrandLab@acs.org

Mariam is an account manager here at C&EN BrandLab. She works with our clients, art and production teams within C&EN to deliver effective ad campaigns. 

Jordan Nutting Ph.D.

Senior Editor
CENBrandLab@acs.org

Jordan is a Senior Editor at C&EN BrandLab. While earning her Ph.D. in chemistry she also pursued her passion for writing and communication, including a stint as a science reporter during the COVID-19 pandemic. She now funnels her love of words and chemistry into creating compelling science stories and content.

Jesse Harris

Senior Editor
CENBrandLab@acs.org

Jesse Harris is a Senior Editor at C&EN BrandLab. He has been creating internet content since 2016, and has Master’s degrees in both chemistry and chemical engineering. He loves helping STEM experts communicate their science more impactfully.

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Shane M Hanlon Ph.D.

Executive Editor
CENBrandLab@acs.org

Shane leads BrandLab’s strategic initiatives and projects. As a conservation biologist turned science communicator and storyteller, Shane brings years of creative and relationship-building experience to BrandLab from his work in the federal government, the National Academies, and scientific membership nonprofits. He is an adjunct professor at the University of Pittsburgh, from which he obtained his B.S. in Ecology and Evolution, and holds a Ph.D. in biology from the University of Memphis.

Heather Lockhart-Neff 

Account & Marketing Manager
CENBrandLab@acs.org

Heather co-leads account management at C&EN BrandLab. She utilizes efficiency and strategy when working with our clients and production teams within C&EN to deliver effective and engaging campaigns. Heather has a passion for telling dynamic stories through multimedia communication channels and brings creativity, curiosity, and charisma to BrandLab partnerships. She obtained her B.S. in International Relations from The College of Wooster in Ohio. 

Cynthia Graham-Tappan 

Managing Director, Sales Strategic Partnerships
CENBrandLab@acs.org

Cynthia Graham-Tappan is an accomplished sales leader with over 15+ years’ experience leading global B2B sales teams within the publishing & media industries.  She has held executive positions with The New York Times, Dow Jones, Agence France Presse, Hearst Corporation and currently oversee Sales & Strategic Partnerships for ACS.   Cynthia has a proven expertise in crafting strategic partnerships, steering high-performing sales teams, and propelling revenue growth. Cynthia also has extensive experience in performance management, market research, digital media monetization, and business development.

Cynthia received her B.S. degree from Towson University and recently completed Executive Education courses with The Yale School of Management and London Business School.  Cynthia resides in Maryland with her husband, and she is a proud mom of four kids.

Kenneth Phan 

Creative Director
CENBrandLab@acs.org

Kenneth is a creative leader with 20 years of experience in in-house and boutique design agencies. He is currently senior creative director for the American Chemical Society’s marketing and communications team. Previously, he was senior creative director for ACS Publications, an international scientific publisher that serves chemistry and related sciences. Kenneth is passionate about translating client business goals into impactful and innovative advertising solutions. Under his leadership, ACS has won numerous awards and accolades for its exceptional design work.